Mode of action analysis of new antibacterial natural products

Advisor: Heike Brötz-Oesterhelt

Location: University of Tübingen

The number of antibiotic-resistant bacteria is increasing worldwide and limits our options to treat bacterial infections. New antibiotics with innovative mechanisms of action are essential to avoid an antibiotic crisis in the future. We determine the molecular modes of action of new antibacterial agents to identify new targets, new pleiotropic modes of killing and new starting points for the development of unprecedented antibiotic drugs. New antibacterial natural products are waiting for a project champion to unravel their secrets! Are you interested in exploring them?

The focus is on the physiological investigation of pathogens under the influence of the new bioactive substances and the molecular characterization of their targets. How does cell death occur? Which metabolic process is primarily affected? What is the binding partner of the antibiotic, and how does the inhibition proceed at the molecular level? Does resistance develop against the active substance? Are there undesirable effects on eukaryotic cells? What are the target's physiological functions and the cell's stress responses in the presence of the bioactive substance?

From the mechanism of action platform established in our group, you will use modern microbiological and molecular biological methods, high-resolution fluorescence microscopy, protein biochemistry, and interaction analysis. In addition, you will establish new technology required for the specific molecular characterization of your active substance.

You should have completed your Master's thesis in a microbiological or biochemical subject area with excellent qualifications. High scientific interest, experimental diligence, an independent working style, and good communication and teamwork skills should characterize you.

We look forward to receiving your application.

More information on Heike Brötz-Oesterhelt and a selection of recent publications can be found on her faculty page.

To apply

  • check that you meet our requirements 
  • familiarize yourself with the application process and have a look at the Frequently Asked Questions
  • To apply, please send: motivation letter, CV, official certificates BSc, MSc, list of methods conducted, summary of Master’s thesis, contact details of two references (one being the professer supervising the Master’s thesis) or reference letters to the advisor.


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