Mode of action analysis of new antibacterial natural products
Advisor: Heike Brötz-Oesterhelt
Location: University of Tübingen
The number of antibiotic-resistant bacteria is soaring worldwide. New antibiotics with innovative mechanisms of action are essential to prevent us from entering a "post-antibiotic" era, with a dramatic decrease in global average lifespan. Our research team determines the molecular modes of action of new antibacterial agents to identify new targets, new pleiotropic modes of killing, and new starting points for developing unprecedented antibiotic drugs. New antibacterial natural products will be studied, among them agents that are produced by and shape the human microbiome.
The focus is on the physiological investigation of pathogens under the influence of new bioactive substances and the molecular characterization of their targets. How exactly do cells die? Which metabolic process is primarily affected? What is the binding partner of the antibiotic, and how does the inhibition work at the molecular level? Does resistance develop fast or slowly? Are there adverse effects on eukaryotic cells? What are the target's physiological functions and the cell's stress responses in the presence of the bioactive substance?
You will profile your agents for the activity against multi-resistant, clinical bacterial pathogens. You will use various microbiological, cell biological and molecular biological methods, bioreporters, OMICs techniques, time-lapse and super-resolution fluorescence microscopy, protein biochemistry, and interaction analysis. An extensive mechanism of action technology platform has been established in our group, which you can draw from (www.imit.uni-tuebingen.de/bioactcompounds). In addition, you will establish new technology required for the specific molecular characterization of your active substances.
You should have completed your Master's thesis in a microbiological or biochemical subject area with excellent qualifications. High scientific interest, experimental diligence, an independent working style, a creative mind, and good communication and teamwork skills should characterize you.
We look forward to receiving your application.
More information on Heike Brötz-Oesterhelt and a selection of recent publications can be found on her faculty page.
To apply
- Check that you meet our requirements
- Familiarize yourself with the application process and have a look at the Frequently Asked Questions
- Register to apply and complete the application form
Application deadline: 27 January 2025