De novo Cytokine Design and Characterisation

Advisor: Mohammad ElGamacy & Andrei Lupas

PhD Program: IMPRS ‘From Molecules to Organisms’
Location: University Hospital Tübingen & Max Planck Institute for Biology

We are looking for a PhD Student (m/f/d) to join our closely collaborating groups at the Max Planck Institute for Biology (Department of Protein Evolution) and the University Hospital Tübingen (Division of Translational Oncology – Department of Internal Medicine II).

Research project:
Using computational design technologies, we aim to create novel proteins with therapeutic potential. In this project, we intend to further our previous work on the development of therapeutic cytokines with enhanced molecular and pharmacological properties. Particularly, the candidate will focus on the de novo design of cytokines that specifically target cells of predefined haematopoietic lineages, with the final aim of treating different types of haematopoietic disorders. The designed molecules will be characterized biophysically and their biological activity will be analysed by applying a wide spectrum of in vitro functional assays and in vivo animal experiments. This offers the doctoral candidate a great opportunity to work across disciplines in protein design, protein biochemistry, and clinical translational research.

Our requirements:

  • Hold, or expect to hold, a Masters (or Diplom) degree in a relevant subject. All prior degree work must be finished before the PhD start date.
  • Have experience in in protein biochemistry, structural biology, or cell biology.
  • Be able to show that your interests, skills and knowledge match well with your proposed area of doctoral research. 
  • Be able to demonstrate a high level of written and spoken English.
  • Have strong motivation to work in international teams.
  • GRE General Test or GATE scores are required from applicants with degrees obtained outside the European Higher Education Area.

We offer:

  • Excellent facilities
  • A fully funded research position (payment level according to E13 65% TVöD Bund). The salary includes all mandatory social insurance contributions for healthcare, unemployment, and retirement benefits
  • Tailored support from your advisor and a thesis advisory committee
  • Opportunities to visit international meetings to present your work
  • Core and optional development opportunities to improve your scientific and transferable skills
  • Multicultural environment with English as the working language

Successful candidates will join the International Max Planck Research School ‘From Molecules to Organisms’.

To apply, please register and complete our online application form.

Application deadline: 5 September 2022

For further information about the research project, please contact Mohammad ElGamacy

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