How to ignore your sister – the molecular basis of interhomolog bias

John Weir
 

 PhD Program: International Max Planck Research School (IMPRS) 'From Molecules to Organisms'
Location: Friedrich Miescher Laboratory 
 

Project description
Meiotic recombination must place between two homologous chromosomes, yet the identical sister chromatid is a much more attractive partner. How is the homologous chromosome chosen? Using recombinant kinases, cohesin complexes and meiosis specific chromatin you will explore the molecular basis of interhomolog bias in vitro. Protein interaction experiments coupled with structural biological approaches will generate detailed models that can be subsequently tested in vivo.

More information about the research of John Weir and a selection of recent publications can be found on his faculty page.

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Application deadline: 8 February 2023