Marcus Hartmann

Molecular recognition and catalysis

Max Planck Institute for Biology Tübingen
IMPRS Adjunct Faculty

Portrait of Marcus Hartmann, a group leader at the MPI for Biology, Tübingen

Vita

  • PhD at the MPI for Developmental Biology, 2006-2012
  • Head of the crystallography facility at the MPI since 2009
  • Project leader at the MPI since 2012
  • Temporary chair of biochemistry at Eberhard Karls University of Tübingen since 2021


Research Interest
We are a structural biochemistry lab trying to understand and manipulate macromolecular machines and systems. For their understanding, we follow a holistic approach, in which we integrate a variety of biophysical, structural and computational approaches and exploit our findings for drug development in multidisciplinary consortia with medicinal chemists.

We pursue two main lines of research. The first focuses on basic research on the spatial organization, functional dynamics, and regulation of biomolecular interactions in metabolic pathways and macromolecular complexes. In the second line, we are exploring promising novel therapeutic approaches, with one focus on targeted protein degradation via the repurposing of E3 ubiquitin ligases for various human pathologies, and another focus on pathogenicity blockers against Salmonella infections.

In the foreground are the enzymatic components of the AROM complex, the background shows scetches of chemical reactions.











 

Model of amidosuccinimide, stylised as a fishing rod, fishing for parts of the human proteome in a bucket.













 


Available PhD Projects

  • Currently not recruiting doctoral researchers.

Selected Reading

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