Nadine Ziemert

Understanding the Evolution and Distribution of Microbial Specialized Metabolites and Developing Bioinformatic tools for Their Discovery as Antibiotics

University of Tübingen
IMPRS Faculty

Vita

Diploma in Biology 2005, Humboldt University Berlin, Germany
PhD work 2005 - 2009 at Humboldt University Berlin, Germany
Postdoctoral Training at Scripps Institution of Oceanography, UCSD, La Jolla, Ca., USA
Research Scientist Position at Scripps Institution of Oceanography, UCSD, La Jolla, Ca.,
W2 - Professor of Natural Product Genome Mining at University Tübingen, 2014-2019
W3 - Professor of Natural Product Genome Mining at University Tübingen, since 2019

Research Interest
The Ziemert Lab at the University of Tübingen investigates the genomic diversity and evolution of natural product biosynthesis in bacteria and fungi. The group combines computational and experimental approaches to discover new antibiotics and other bioactive compounds. Its research integrates comparative genomics, pangenomics, metagenomics, and genome mining with molecular biology and analytical chemistry to link biosynthetic gene clusters (BGCs) to their chemical products and biological functions. The lab develops and maintains widely used computational tools and databases for genome mining and collaborates closely with microbiologists and chemists to validate predictions and explore the ecological and therapeutic roles of microbial natural products.

The antibiotic-resistant target seeker is one of the Ziemert lab´s genome mining tools created to facilitate the bioactivity prediction of antibiotics encoded in microbial gene clusters.

The antibiotic-resistant target seeker is one of the Ziemert lab´s genome mining tools created to facilitate the bioactivity prediction of antibiotics encoded in microbial gene clusters.

Available PhD Projects in the IMPRS

Currently not recruiting doctoral researchers.

Selected Reading

Negri T, Mantri S, Angelov A, Peter S, Muth G, Eustaquio A and Ziemert N. (2022). A rapid and efficient strategy to identify and recover biosynthetic gene clusters from soil metagenomes. Applied Microbiology and Biotechnology. doi: 10.1007/s00253-022-11917-y
Gavriilidou A, Kautsar SA, Zaburannyi N, Krug D, Mueller R, Medema MH and Ziemert N. (2022). Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes. Nature Microbiology. doi: 10.1038/s41564-022-01110-2
Mantri SS, Negri, T, Sales-Ortells H, Angelov A, Peter, S, Neidhardt H, Oelmann Y, Ziemert N. (2021). Metagenomic Sequencing of Multiple Soil Horizons and Sites in Close Vicinity Revealed Novel Secondary Metabolite Diversity. mSystems.doi: 10.1128/mSystems.01018-21
Mungan MD, Blin K, Ziemert N. (2021). ARTS-DB: a Database for Antibiotic Resistant Targets. Nucleic Acids Research. doi: 10.1093/nar/gkab940
Bruns H, Crüsemann M, Letzel AC, Alanjary M, McInerney JO, Jensen PR, Schulz S, Moore BS, Ziemert N. (2015). Function-related replacement of bacterial siderophore pathways. The ISME journal. doi: 10.1038/ismej.2017.137