Understanding the Evolution and Distribution of Microbial Specialized Metabolites and Developing Bioinformatic tools for Their Discovery as Antibiotics
University of Tübingen
Faculty in: IMPRS
- Diploma in Biology 2005, Humboldt University Berlin, Germany
- PhD work 2005 - 2009 at Humboldt University Berlin, Germany
- Postdoctoral Training at Scripps Institution of Oceanography, UCSD, La Jolla, Ca., USA
- Research Scientist Position at Scripps Institution of Oceanography, UCSD, La Jolla, Ca.,
- W2 - Professor of Natural Product Genome Mining at University Tübingen, 2014-2019
- W3 - Professor of Natural Product Genome Mining at University Tübingen, since 2019
The Ziemert lab is interested in the evolution and distribution of bacterial specialized (also called secondary) metabolites. These bioactive compounds are especially important in human medicine as the chemical scaffolds are the main templates for new drugs such as antibiotics and anticancer agents. We are a highly interdisciplinary group at the interface of bioinformatics, molecular and environmental microbiology, biochemistry and phylogenetics and are currently developing bioinformatic tools for the discovery of natural products from microbial genomes, elucidating the evolutionary history of their biosynthetic gene clusters and tracing their distribution in the environment using genomic and metagenomic data.
Available PhD Projects in the IMPRS
- Currently not recruiting PhD students
- Negri T, Mantri S, Angelov A, Peter S, Muth G, Eustaquio A, Ziemert N: A rapid and efficient strategy to identify and recover biosynthetic gene clusters from soil metagenomes. Appl. Microbiol. Biotechnol., 2022, 106 (8), 3293-3306.
- Gavriilidou A, Kautsar SA, Zaburannyi N, Krug D, Mueller R, Medema MH, Ziemert N: A global survey of specialized metabolic diversity encoded in bacterial genomes, Nature Microbiology, 2022, 7 (5), 726-735.
- Mantri SS, Negri, T, Sales-Ortells H, Angelov A, Peter, S, Neidhardt H, Oelmann Y, Ziemert N: Metagenomic Sequencing of Multiple Soil Horizons and Sites in Close Vicinity Revealed Novel Secondary Metabolite Diversity, mSystems, 2021, 6 (5), e01018-21.
- Mungan MD, Blin K, Ziemert N: ARTS-DB: a Database for Antibiotic Resistant Targets., Nucleic Acids Res. 2021, 50 (D1), D736-D740.
- Bruns H, Crüsemann M, Letzel AC, Alanjary M, McInerney JO, Jensen PR, Schulz S, Moore BS, Ziemert N.: Function-related replacement of bacterial siderophore pathways. ISME J. 2017 Aug 15.