Oliver Kohlbacher

Method development in computational biology

University of Tübingen
Faculty in: IMPRS

Portrait of Oliver Kohlbacher in his office.

Vita

PhD in Computer Science 2001, Saarland University
Group Leader 2000-03, Center for Bioinformatics, Saarbrücken
Post-doctoral training 2001-2002, Celera Genomics, Rockville, Maryland
Professor of Applied Bioinformatics, University of Tübingen since 2003
Director, Quantitative Biology Center, University of Tübingen since 2012
Fellow, MPI for Biology Tübingen 2015-2020
Director, Institute for Translational Bioinformatics, University Hospital Tübingen, since 2018
Director, Institute for Bioinformatics and Medical Informatics, University of Tübingen, since 2020

Research Interest
The research of our group is focused on method development in computational biology and their application in systems biology, drug design, and immunology. We focus on the analysis of high-throughput data from genomics, transcriptomics, proteomics, and metabolomics. To this end we develop algorithmic and statistical techniques to analyze these data and integrate them into the biological context. The group is also known for its open-source software development efforts, most notably OpenMS (computational mass spectrometry) and BALL (structural bioinformatics).

Available PhD Projects

Currently not recruiting PhD students.

Selected Reading

Singh J, Elhabashy H, Muthukottiappan P, Stepath M, Eisenacher M, Kohlbacher O, Gieselmann V, Winter D, (2022). Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo.Nat Commun. 13(1):6212.
Green AG, Elhabashy H, Brock KP, Maddamsetti R, Kohlbacher O, Marks DS, (2021) Large-scale discovery of protein interactions at residue resolution using co-evolution calculated from genomic sequences. Nat Commun. Mar 2;12(1):1396.
Hopf, TA, Schärfe, CPI, Rodrigues, JP, Green, AG, Kohlbacher, O, Sander, C, Bonvin, AM, and Marks, DS (2014). Sequence co-evolution gives 3D contacts and structures of protein complexes. elife: 10.7554/eLife.03430.
Kramer, K, Sachsenberg, T, Beckmann, BM, Qamar, S, Boon, K, Hentze, MW, Kohlbacher, O, and Urlaub, H (2014). Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins. Nat. Methods, 11(10):1064-70. doi: https://doi.org/10.1038/nmeth.3092
Ziller, MJ, Gu, H, Müller, F, Donaghey, J, Kohlbacher, O, Bernstein, BE, Gnirke, A, and Meissner, A (2013). Charting a dynamic DNA methylation landscape of the human genome. Nature, 500:477–481, doi: 10.1038/nature12433 .